Metacarpophalangeal pattern profile analysis in Brachmann-de Lange syndrome
| Autor: | Gale Dd, Dahir Ga, Meaney Fj, Merlin G. Butler |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent business.industry Discriminant Analysis Infant Article Classification rate Child Preschool De Lange Syndrome Brachmann de Lange syndrome medicine Humans Female Profile analysis Metacarpus Child business Hand Deformities Congenital Genetics (clinical) |
| Zdroj: | American Journal of Medical Genetics. 47:1003-1005 |
| ISSN: | 1096-8628 0148-7299 |
| DOI: | 10.1002/ajmg.1320470713 |
| Popis: | We analyzed the metacarpophalangeal pattern profile (MCPP) of 19 individuals with Brachmann-de Lange syndrome (BDLS) and calculated a mean syndrome profile. Fourteen of 19 individuals with BDLS had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with BDLS compared with a sample of normal individuals produced a correct classification rate of 100% based on a function of 2 MCPP variables that may provide a useful tool for assisting in the diagnosis of BDLS. An average pattern variability index calculated for the BDLS patients was 1.9 indicating an abnormal hand pattern in this syndrome. |
| Databáze: | OpenAIRE |
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