Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Autor: Ricardo Lopez-Muñoz, Zoila Vaquera, Eliud Silva, Angélica Martínez-Hernández, Shelley A. Cole, Anthony G. Comuzzie, Areli Murillo-Ramirez, Xianlin Han, José Ángeles-Chimal, Juan Carlos López-Alvarenga, Fernanda Molina-Segui, Martha Eunice Rodríguez-Arellano, Víctor M Hernández-Escalante, Karin Haack, Rosa A. Veloz-Garza, Edna J. Nava-González, José María Remes-Troche, Antonio Laviada-Nagel, Ruy David Arjona-Villicaña, Rebeca Espadas-Olivera, Vanessa Giselle Peschard, Monica Acebo-Martinez, Salvador B. Valdovinos-Chavez, Francisco Barajas-Olmos, Fabiola Escalante-Araiza, Rocio A. Salinas-Osornio, Sara P. Diaz-Tena, Susan T. Weintraub, Ernesto Rodríguez-Ayala, Juan Carlos Castillo-Pineda, Juan Manuel Viveros-Paredes, Jack W. Kent, Esther C. Gallegos-Cabrales, Hugo Laviada-Molina, Jesús Santa-Olalla Tapia, Irene Leal-Berumen, Lucia Gonzalez-Ramirez, Rafael Garzon-Zamora, Laura Gonzalez-Lopez, Eira E. Huerta-Avila, Judith Cornejo-Barrera, Huertas Quintero Jancy Andrea, Fatima A. Buenfil-Rello, Claudia Escudero-Lourdes, Benigno Figueroa-Nuñez, Raul A. Bastarrachea, Lorena Orozco, Janeth F. Gaytan-Saucedo, Melesio E. Valencia-Rendon
Rok vydání: 2020
Předmět:
Male
Physiology
immunometabolism
Adipose tissue
Cardiovascular
Pathogenesis
Cohort Studies
chemistry.chemical_compound
Risk Factors
Medicine
QP1-981
2.1 Biological and endogenous factors
Precision Medicine
Aetiology
Leptin
Diabetes
Fasting
Lipids
Postprandial
Phenotype
non-coding microRNAs
Adipose Tissue
Adipose tissue dysfunction
Female
Research Paper
Adult
medicine.medical_specialty
Histology
Diseases of the endocrine glands. Clinical endocrinology
Insulin resistance
Clinical Research
Internal medicine
Humans
Obesity
shotgun lipidomics
Metabolic and endocrine
Nutrition
Adiponectin
Triglyceride
QH573-671
business.industry
Cell Biology
Shotgun lipidomics
medicine.disease
RC648-665
postprandial tissue biopsies
Endocrinology
Good Health and Well Being
chemistry
Insulin Resistance
business
Cytology
Zdroj: Adipocyte, vol 9, iss 1
Adipocyte
Adipocyte, Vol 9, Iss 1, Pp 153-169 (2020)
Popis: Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders.
Databáze: OpenAIRE
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