Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia
| Autor: | Lisa J. Campbell, Carrie Fidler, Helen Eagleton, Jacqueline Boultwood, Tim Littlewood, Andrea Pellagatti, Fiona Watkins, Noor Esoof, James S. Wainscoat, Nicholas C.P. Cross |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Myeloid Tumor suppressor gene DNA Mutational Analysis CD34 A Kinase Anchor Proteins Down-Regulation Antigens CD34 Cell Cycle Proteins Biology medicine.disease_cause Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Internal medicine Precursor cell medicine Humans Hematology Reverse Transcriptase Polymerase Chain Reaction Myelodysplastic syndromes Proteins medicine.disease Neoplasm Proteins Cell Transformation Neoplastic medicine.anatomical_structure Real-time polymerase chain reaction Leukemia Myeloid Myelodysplastic Syndromes Acute Disease Immunology Cancer research Blast Crisis Carcinogenesis |
| Zdroj: | British Journal of Haematology. 126:508-511 |
| ISSN: | 0007-1048 |
| Popis: | The putative tumour suppressor gene gravin is down-regulated in several solid tumours and is implicated in tumorigenesis. We have evaluated the expression levels of the gravin gene in the CD34(+)/blast cells of a range of myeloid malignancies as compared with controls using real-time quantitative polymerase chain reaction (PCR). Gravin was markedly down-regulated in 41 of 41 patients with acute myeloid leukaemia (AML), nine of 10 patients with myelodysplastic syndromes (MDS) and 33 of 33 patients with chronic myeloid leukaemia (CML), of whom 24 were in blast crisis (BC). We have shown that gravin is consistently down-regulated in the CD34(+)/blast cells of myeloid malignancies and may play a role in the molecular pathogenesis of these disorders. |
| Databáze: | OpenAIRE |
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