Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala
| Autor: | Rebecca Hao, E. Ordoñes Sanchez, Alex S. Kowalczyk, Cheryl S. Rosenfeld, Gian D. Greenberg, Emily C. Wright, S. A. Johnson, Brian C. Trainor, Abigail Laman-Maharg |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Endocrinology Diabetes and Metabolism Ethinyl Estradiol DNA Methyltransferase 3A California mouse Social defeat chemistry.chemical_compound Mice 0302 clinical medicine Endocrinology DNA (Cytosine-5-)-Methyltransferases Sex Characteristics Amygdala oestrogen receptor Mental Health medicine.anatomical_structure endocrine disruptors DNA methylation embryonic structures Female Sex characteristics DNA (Cytosine-5-)-Methyltransferase 1 medicine.medical_specialty Clinical Sciences Biology Stress Basic Behavioral and Social Science DNA methyltransferase Article 03 medical and health sciences Cellular and Molecular Neuroscience Endocrinology & Metabolism Phenols Internal medicine Behavioral and Social Science Genetics medicine Animals Benzhydryl compounds Benzhydryl Compounds Social Behavior Endocrine and Autonomic Systems DNMT1 Neurosciences Good Health and Well Being 030104 developmental biology chemistry Psychological DNMT3A Stress Psychological 030217 neurology & neurosurgery Basolateral amygdala |
| Zdroj: | Journal of neuroendocrinology, vol 29, iss 6 Wright, EC; Johnson, SA; Hao, R; Kowalczyk, AS; Greenberg, GD; Ordoñes Sanchez, E; et al.(2017). Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala. Journal of Neuroendocrinology, 29(6). doi: 10.1111/jne.12475. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6xf833nq |
| Popis: | © 2017 British Society for Neuroendocrinology Chemical and psychological stressors can exert long lasting changes in brain function and behaviour. Changes in DNA methylation have been shown to be an important mechanism mediating long lasting changes in neural function and behaviour, especially for anxiety-like or stress responses. In the present study, we examined the effects of either a social or chemical stressor on DNA methyltransferase (DNMT) gene expression in the amygdala, an important brain region modulating stress responses and anxiety. In adult California mice (Peromyscus californicus) that were naïve to social defeat, females had higher levels of Dnmt1 expression in punch samples of the central amygdala (CeA) than males. In addition, mice that underwent social defeat stress showed reduced Dnmt1 and Dnmt3a expression in the CeA of females but not males. A second study using more anatomically specific punch samples replicated these effects for Dnmt1. Perinatal exposure (spanning from periconception through lactation) to bisphenol A or ethinyl oestradiol (oestrogens in birth control pills) also abolished sex differences in Dnmt1 expression in the CeA but not the basolateral amygdala. These findings identify a robust sex difference in Dnmt1 expression in the CeA that is sensitive to both psychological and chemical stressors. Future studies should aim to examine the impact of psychological and chemical stressors on DNA methylation in the CeA and also investigate whether Dnmt1 may have an underappreciated role in plasticity in behaviour. |
| Databáze: | OpenAIRE |
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