Preimplantation biopsy predicts delayed graft function, glomerular filtration rate and long-term graft survival of transplanted kidneys
| Autor: | Maria Paola Salerno, Tullio Faraggiana, Valentina Pietroni, Evaldo Favi, José Alberto Rodrigues Pedroso, A. Toscano, Jacopo Romagnoli, Valentina Bianchi, Franco Citterio, Konstantinos Giannakakis, Gionata Spagnoletti |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry graft survival Renal function Patient survival General Medicine lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 Graft function Predictive value Delayed Graft Function Surgery preimplantation biopsies surgical procedures operative delayed graft function patient survival prediction scores time-zero biopsies Biopsy Medicine Graft survival business |
| Zdroj: | Nephrology @ Point of Care, Vol 2, Iss 1, Pp 1-7 (2016) |
| Popis: | BackgroundThe predictive value of preimplantation biopsies for long-term graft function is often limited by conflicting results. The aim of this study was to evaluate the influence of time-zero graft biopsy histological scores on early and late graft function, graft survival and patient survival, at different time points.MethodsWe retrospectively analyzed 284 preimplantation biopsies at a single center, in a cohort of recipients with grafts from live and deceased donors (standard and nonstandard), and their impact in posttransplant renal function after a mean follow-up of 7 years (range 1–16). Implantation biopsy score (IBS), a combination score derived from 4 histopathological aspects, was determined from each sample. The correlation with incidence of delayed graft function (DGF), creatinine clearance (1st, 3rdand 5thposttransplant year) and graft and patient survival at 1 and 5 years were evaluated.ResultsPreimplantation biopsies provided somewhat of a prognostic index of early function and outcome of the transplanted kidney in the short and long term. In the immediate posttransplantation period, the degree of arteriolosclerosis and interstitial fibrosis correlated better with the presence of DGF. IBS values between 4 and 6 were predictive of worst renal function at 1stand 3rdyears posttransplant and 5-year graft survival. The most important histological finding, in effectively transplanted grafts, was the grade of interstitial fibrosis. Patient survival was not influenced by IBS.ConclusionsHigher preimplantation biopsy scores predicted an increased risk of early graft losses, especially primary nonfunction. Graft survival (at 1stand 5thyears after transplant) but not patient survival was predicted by IBS. |
| Databáze: | OpenAIRE |
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