Associations of High-Density Lipoprotein Cholesterol and Framingham Cardiovascular Risk in African Type 2 Diabetics with Diabetic Retinopathy
| Autor: | Igor Longo Phemba, Steve Cook, Moise Mvitu Muaka, Benjamin Longo-Mbenza, Emmanuel Mve Mengome, Thierry Raoul Gombet |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Framingham Risk Score medicine.diagnostic_test Cholesterol business.industry Public health nutritional and metabolic diseases Diabetic retinopathy medicine.disease Logistic regression smoking chemistry.chemical_compound High-density lipoprotein Insulin resistance chemistry Eye examination Internal medicine insulin resistance visual disability medicine oxidative stress business higher high-density lipoprotein Africans |
| DOI: | 10.5281/zenodo.4936009 |
| Popis: | Objectives: To assess the associations of high-density lipoprotein cholesterol (HDL-C) and Framingham cardiovascular (CVD) with diabetic retinopathy (DR). DR is the most frequent cause of visual disability (VD) worldwide. Methods: A cross-sectional study of random sample of 200 T2DM Central Africans. Socio-biographical, laboratory and eye examination main outcome measures were investigated using Tertiles of HDL-C (stratification = lowest Results: Out of 200 T2DM patients, 120 (35.5%) had DR and out of DR patients, 116 (n = 96.7%) had VD. There was a significant U- shaped relationship between DR rates and HDL-C stratification. In the normal HDL-C group, elevated 8-hydroxydeoxyguanosine and 10-year Framingham risk > 10% were the significant independent determinants for DR. In the highest HDL-C group, smoking status and 10-year Framingham risk ≥ 10% were the significantly independent determinants for DR. In 10-year Framingham risk ≥ 10% group, smoking status, insulin resistance and increasing levels of HDL-C were the significant independent determinants for DR. Conclusion: DR and VD remain a public health problem in T2DM Central Africans. Some Central Africans with DR and VD appear to have higher HDL-C than T2DM Central Africans without DR and VD. HDL-C in T2DM patients with DR, may be more tightly controlled by genetic factors (black Bantu ethnicity) than the other lipoproteins as reported among Indians, African-Americans, and Japanese individuals. The most preventable environmental risk factors for DR were smoking status, global cardiovascular disease risk, insulin resistance and oxidative stress. |
| Databáze: | OpenAIRE |
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