Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys
| Autor: | Naoki Sato, Amelia B. Kudej, Kuniya Asai, Sanford P. Bishop, Jerome B. Nazareno, Stephen F. Vatner, Gen Takagi, You-Tang Shen, Filipinas F. Natividad, Gui Ping Yang, Yong Jian Geng, Dorothy E. Vatner, Raymond K. Kudej |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Nitroprusside Aging Cardiac output medicine.medical_specialty Endothelium Vasodilator Agents Aorta Thoracic Apoptosis Blood Pressure Cell Count Femoral artery biology.animal medicine.artery Internal medicine In Situ Nick-End Labeling medicine Animals Primate Aorta Abdominal Endothelial dysfunction Aorta TUNEL assay biology medicine.disease Acetylcholine Femoral Artery Macaca fascicularis medicine.anatomical_structure Endocrinology Vascular Resistance Endothelium Vascular Sodium nitroprusside Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 20:1493-1499 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.20.6.1493 |
| Popis: | Abstract —To determine the effects of aging on vasoactivity in a primate model ( Macaca fascicularis ), 13 young male monkeys (aged 7.1±0.4 years) and 9 old male monkeys (aged 19.8±0.6 years) were chronically instrumented for measurement of left ventricular and aortic pressures and cardiac output. Total cholesterol, triglyceride, and fasting blood sugar levels were not different between the 2 groups. There were no significant differences in baseline mean aortic pressure and total peripheral resistance (TPR) in the young monkeys versus the old monkeys. TPR fell less ( P P r =0.62, P =0.013) between the incidence of terminal deoxynucleotidyl transferase–mediated dUTP nick end-labeling (TUNEL)-positive endothelial cells and endothelial cell density in the femoral artery. The reduced endothelial cell density was also correlated ( r =0.82, P |
| Databáze: | OpenAIRE |
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