Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
| Autor: | Seyed Alireza Vafaei, Masoumeh Taheri Azandaryani, Ali Darini, Fatemeh Mirzaei, Farhad Kian Ara, Nima Naseri, Ebrahim Abbasi |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology medicine.medical_treatment CCL4 QD415-436 Liver injury medicine.disease_cause Biochemistry digestive system chemistry.chemical_compound Internal medicine medicine QP1-981 Carbon tetrachloride Inflammation Fatty liver Cerium oxide nanoparticles General Medicine Glutathione Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue Malondialdehyde medicine.disease digestive system diseases Rats Endocrinology chemistry Oxidative stress |
| Zdroj: | Metabolism Open Metabolism Open, Vol 12, Iss, Pp 100151-(2021) |
| ISSN: | 2589-9368 |
| Popis: | Background and aims Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO2 NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO2 NPs in two models of liver injury, non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride (CCl4)-induced liver fibrosis, in rats. Methods In this experimental study, male rats were randomly divided into different experimental groups including: Experiment 1; group1: healthy rats received normal saline, 2: CCl4 group, 3: CCl4 + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore. Results Total antioxidant capacity (TAC) and glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and total oxidant status (TOS) were significantly increased in the liver, and intestine of the NAFLD and CCl4 group compared with control rats. However, the use of nanoparticles significantly normalized these markers. The levels of the TNF-α were significantly reduced in the nanoparticle group as compared with NAFLD model and CCl4-treated rats. CeO2 NPs also normalized the liver and intestinal histological changes. Conclusions Our finding revealed that CeO2 NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation. |
| Databáze: | OpenAIRE |
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