Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
| Autor: | Charles J. Di Como, Stephanie A. Robertson, Kellie Whittaker, Michael Martin Ollmann, Lori Friedman, Andrew Roy Buchman, Casey Kopczynski, Geoffrey Duyk, Carol Prives, Lynn M. Young, Madelyn Robin Demsky, William W Fisher, Marcia Belvin, Felix D. Karim |
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| Rok vydání: | 2000 |
| Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
Cell cycle checkpoint DNA damage Molecular Sequence Data Apoptosis Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology law.invention law Cyclins medicine Animals Humans Genes Tumor Suppressor Amino Acid Sequence Binding Sites Sequence Homology Amino Acid Biochemistry Genetics and Molecular Biology(all) G1 Phase Intracellular Signaling Peptides and Proteins Proteins Molecular biology Cell biology Drosophila melanogaster Suppressor Insect Proteins Tumor Suppressor Protein p53 Carcinogenesis G1 phase Function (biology) Cell Division P53 binding |
| Zdroj: | Cell. 101(1) |
| ISSN: | 0092-8674 |
| Popis: | The importance of p53 in carcinogenesis stems from its central role in inducing cell cycle arrest or apoptosis in response to cellular stresses. We have identified a Drosophila homolog of p53 (" Dmp53 "). Like mammalian p53, Dmp53 binds specifically to human p53 binding sites, and overexpression of Dmp53 induces apoptosis. Importantly, inhibition of Dmp53 function renders cells resistant to X ray–induced apoptosis, suggesting that Dmp53 is required for the apoptotic response to DNA damage. Unlike mammalian p53, Dmp53 appears unable to induce a G1 cell cycle block when overexpressed, and inhibition of Dmp53 activity does not affect X ray–induced cell cycle arrest. These data reveal an ancestral proapoptotic function for p53 and identify Drosophila as an ideal model system for elucidating the p53 apoptotic pathway(s) induced by DNA damage. |
| Databáze: | OpenAIRE |
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