Effect of Cisplatin on the Basement Membrane Anionic Sites in the Ampulla, Macula, and Stria Vascularis of Guinea Pigs
Autor: | Mitsuya Suzuki, Kimitaka Kaga |
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Rok vydání: | 1997 |
Předmět: |
Pathology
medicine.medical_specialty animal structures Guinea Pigs Drug Evaluation Preclinical Antineoplastic Agents macromolecular substances Biology Basement Membrane Bony labyrinth Guinea pig 03 medical and health sciences 0302 clinical medicine Ototoxicity Acoustic Maculae otorhinolaryngologic diseases medicine Animals Polyethyleneimine Inner ear 030223 otorhinolaryngology Ampulla Cisplatin Basement membrane technology industry and agriculture Stria Vascularis General Medicine medicine.disease Semicircular Canals medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Dark cell Vestibule Labyrinth sense organs medicine.drug |
Zdroj: | Annals of Otology, Rhinology & Laryngology. 106:971-975 |
ISSN: | 1943-572X 0003-4894 |
Popis: | Our objective was to compare changes in the basement membrane anionic sites (BMAs) in the ampulla, macula, and stria vascularis following the infusion of cisplatin (CDDP). After CDDP was administered to anesthetized Hartley guinea pigs, the bony labyrinth was immersed in a solution of polyethyleneimine (PEI). The size and distribution of PEI particles associated with BMAs in the stria vascularis and in the dark cell and sensory cell areas of the vestibular labyrinth were determined by electron microscopy. A significant reduction in the number and size of PEI particles was observed on CDDP-treated strial vessels. The number and size of PEI particles on the basement membranes of the vestibular labyrinth did not differ from those in the control. Our findings suggest that the BMAs of the vestibular labyrinth were not significantly affected by the administration of a single dose of CDDP. |
Databáze: | OpenAIRE |
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