BDNF Val66Met polymorphism influence on striatal blood-level-dependent response to monetary feedback depends on valence and agency
| Autor: | Justin R. Chumbley, Jakub Späti, Simona Spinelli, Nadja Dörig, Erich Seifritz, Janis Brakowski, M. Grosse Holtforth |
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| Přispěvatelé: | University of Zurich, Spinelli, S |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Genotyping Techniques Psychometrics Feedback Psychological Neuroscience(all) Motion Perception Val66met polymorphism 610 Medicine & health Striatum Neuropsychological Tests Polymorphism Single Nucleotide White People 170 Ethics Young Adult Val66Met Neurotrophic factors medicine Humans 10237 Institute of Biomedical Engineering Valence (psychology) 10. No inequality feedback processing Brain Mapping medicine.diagnostic_test 10093 Institute of Psychology General Neuroscience Brain-Derived Neurotrophic Factor Ventral striatum 2800 General Neuroscience Cognition Middle Aged medicine.disease functional magnetic resonance imaging Magnetic Resonance Imaging Self Concept Frontal Lobe medicine.anatomical_structure Cerebrovascular Circulation Ventral Striatum Major depressive disorder Female inferior frontal junction Functional magnetic resonance imaging Psychology 150 Psychology Neuroscience Reinforcement Psychology Brain-derived neurotrophic factor gene |
| Zdroj: | Chumbley, J.; Späti, J.; Dörig, N.; Brakowski, J.; grosse Holtforth, Martin; Seifritz, E.; Spinelli, S. (2014). BDNF Val66Met polymorphism influence on striatal blood-level-dependent response to monetary feedback depends on valence and agency. Neuroscience, 280, pp. 130-141. Elsevier 10.1016/j.neuroscience.2014.09.014 Neuroscience |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2014.09.014 |
| Popis: | Animal work implicates the brain-derived neurotrophic factor (BDNF) in function of the ventral striatum (VS), a region known for its role in processing valenced feedback. Recent evidence in humans shows that BDNF Val66Met polymorphism modulates VS activity in anticipation of monetary feedback. However, it remains unclear whether the polymorphism impacts the processing of self-attributed feedback differently from feedback attributed to an external agent. In this study, we emphasize the importance of the feedback attribution because agency is central to computational accounts of the striatum and cognitive accounts of valence processing. We used functional magnetic resonance imaging and a task, in which financial gains/losses are either attributable to performance (self-attributed, SA) or chance (externally-attributed, EA) to ask whether BDNF Val66Met polymorphism predicts VS activity. We found that BDNF Val66Met polymorphism influenced how feedback valence and agency information were combined in the VS and in the right inferior frontal junction (IFJ). Specifically, Met carriers’ VS response to valenced feedback depended on agency information, while Val/Val carriers’ VS response did not. This context-specific modulation of valence effectively amplified VS responses to SA losses in Met carriers. The IFJ response to SA losses also differentiated Val/Val from Met carriers. These results may point to a reduced allocation of attention and altered motivational salience to SA losses in Val/Val compared to Met carriers. Implications for major depressive disorder are discussed. |
| Databáze: | OpenAIRE |
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