Percutaneous absorption of flufenamic acid in rabbits: effect of dimethyl sulfoxide and various nonionic surface-active agents
| Autor: | August G. Danti, Chiaw-Chi Hwang |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Chromatography
Time Factors Chemistry Dimethyl sulfoxide Skin Absorption SORBITAN TRIOLEATE Pharmaceutical Science Ether Flufenamic Acid Ointments medicine.drug_formulation_ingredient chemistry.chemical_compound Surface-Active Agents Flufenamic acid Stearate Percutaneous absorption medicine Organic chemistry Animals Dimethyl Sulfoxide Rabbits White petrolatum Surface-active agents medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 72(8) |
| ISSN: | 0022-3549 |
| Popis: | □ Eight nonionic surface-active agents were each incorporated at a concentration of 10% into a white petrolatum ointment base containing 10% flufenamic acid with or without dimethyl sulfoxide. Percutaneous absorption was studied by determining.the plasmaconcentration of flufenamic acid in New Zealand White rabbits at regular intervals for 8 hr following application of the ointment. The percutaneous absorption of flufenamic acid was significantly increased when sorbitan trioleate, polyoxyl 8 stearate, or polyoxyethylene 2 oleyl ether were added to the ointment containing flufenamic acid and white petrolatum. The percutaneous absorption of flufenamic acid was increased significantly when sorbitan monopalmitate, sorbitan trioleate, polyoxyl 8 stearate, polyoxyethylene 20 cetyl ether, or polyoxyethylene 2 oleyl ether were added to the ointment containing dimethyl sulfoxide, flufenamic acid, and white petrolatum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text