Association of Pulmonary Tuberculosis with Increased Dietary Iron
| Autor: | Nyasha L. Murphree, Johan R. Boelaert, Z. A. R. Gomo, Thokozile Saungweme, Ishmael Kasvosve, Innocent T. Gangaidzo, Victor M. Moyo, Victor R. Gordeuk, Hlosukwazi Khumalo, George Aggrey, Tracey A. Rouault, Elisha Mvundura |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Rural Population Zimbabwe medicine.medical_specialty Tuberculosis Antitubercular Agents Comorbidity Gastroenterology Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine Immunopathology HIV Seropositivity Odds Ratio medicine Humans Immunology and Allergy Risk factor Sida Tuberculosis Pulmonary biology business.industry Hazard ratio Respiratory disease Beer biology.organism_classification medicine.disease Confidence interval Infectious Diseases Immunology Female business Iron Dietary |
| Zdroj: | The Journal of Infectious Diseases. 184:936-939 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/323203 |
| Popis: | To determine whether increased dietary iron could be a risk factor for active tuberculosis, dietary iron history and human immunodeficiency virus (HIV) status were studied in 98 patients with pulmonary tuberculosis and in 98 control subjects from rural Zimbabwe. Exposure to high levels of dietary iron in the form of traditional beer is associated with increased iron stores in rural Africans. HIV seropositivity was associated with a 17.3-fold increase in the estimated odds of developing active tuberculosis (95% confidence interval [95% CI], 7.4‐ 40.6; ), and increased dietary iron was associated with a 3.5-fold increase (95% CI, P ! .001 1.4‐8.9; ). Among patients treated for tuberculosis, HIV seropositivity was associated P p .009 with a 3.8-fold increase in the estimated hazard ratio of death (95% CI, 1.0‐13.8; ), P p .046 and increased dietary iron was associated with a 1.3-fold increase (95% CI, 0.4‐6.4; ). P p .2 These findings are consistent with the hypothesis that elevated dietary iron may increase the risk of active pulmonary tuberculosis. |
| Databáze: | OpenAIRE |
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