New endoscopic method for gastric hypersensitivity testing: Pilot study
| Autor: | Shintaro Hoshino, Mitsuru Kaise, Yoshimasa Hoshikawa, Tomohide Tanabe, Katsuhiko Iwakiri, Mai Koeda, Saori Kanai, Eri Momma, Noriyuki Kawami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Insufflation
medicine.medical_specialty dyspepsia RC799-869 Gastroenterology External pressure 03 medical and health sciences 0302 clinical medicine Functional gastrointestinal disorder Internal medicine medicine Hypersensitivity test Hepatology Receiver operating characteristic business.industry Stomach digestive oral and skin physiology Original Articles functional gastrointestinal disorder Diseases of the digestive system. Gastroenterology medicine.disease Gastric pressure digestive system diseases Compliance (physiology) medicine.anatomical_structure diagnostic test 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Original Article hypersensitivity business |
| Zdroj: | JGH Open, Vol 5, Iss 5, Pp 614-621 (2021) JGH Open: An Open Access Journal of Gastroenterology and Hepatology |
| ISSN: | 2397-9070 |
| Popis: | Background and Aim Although one of the causes of dyspeptic symptoms in functional dyspepsia patients is gastric hypersensitivity, there is currently no routine endoscopic gastric hypersensitivity test. We developed a new endoscopic method for gastric hypersensitivity testing. The aim of the present study was to investigate whether this method is useful for evaluating gastric hypersensitivity in drug‐resistant functional dyspepsia patients who were strongly suspected of having gastric hypersensitivity. Methods Twenty‐seven drug‐resistant functional dyspepsia patients and 27 nonfunctional dyspepsia patients were recruited. Gastric pressure was assessed using an external pressure transducer, and the CO2 insufflation volume was measured using an endoscopic CO2‐supplied device and flow meter. The following variables were examined: gastric pressure at baseline and gastric pressure, the CO2 insufflation volume, and compliance of the stomach when patients initially felt abdominal tension following CO2 insufflation. Results No significant differences were observed in baseline gastric pressure or compliance of the stomach between the groups. Drug‐resistant functional dyspepsia patients had a significantly smaller CO2 insufflation volume and lower gastric pressure when symptoms developed than nonfunctional dyspepsia patients. Based on a cutoff value of 1.25 L by receiver operating characteristic curves, sensitivity and specificity for gastric pressure were 85.0 and 96.3%, respectively. Similarly, based on a cutoff value of 12.7 mmHg, sensitivity and specificity for the CO2 insufflation volume were 81.5 and 81.5%, respectively. Conclusion This endoscopic gastric hypersensitivity testing is a useful tool for evaluating the presence of gastric hypersensitivity. We developed a method to measure gastric pressure and the CO2 injection volume during endoscopy. Drug‐resistant functional dyspepsia (FD) patients who were strongly suspected of having gastric hypersensitivity developed abdominal symptoms at a smaller CO2 volume and lower gastric pressure than non‐FD patients. This new endoscopic test is a useful tool for evaluating the presence of gastric hypersensitivity. |
| Databáze: | OpenAIRE |
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