Histopathological lesions in encephalon and heart of mice infected with Toxoplasma gondii increase after Lycopodium clavatum 200dH treatment
| Autor: | Andréia Vieira Pereira, Katiucha Rebeca Jennifer Lopes Lera, Idessania Nazareth Costa, Denise Lessa Aleixo, Wander Rogério Pavanelli, Ricardo Nascimento Drozino, Mário dos Anjos Neto Filho, Marcelo Biondaro Góis, Gislane Janaina Falkowski-Temporini, Silvana Marques de Araújo, Paula Fernanda Massini, Milena Menegazzo Miranda, Ivete Conchon-Costa, Paulo da Silva Watanabe |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Lycopodium clavatum Pathology medicine.medical_specialty Myocarditis Parasitemia Lycopodium Peripheral blood mononuclear cell Pathology and Forensic Medicine Mice 03 medical and health sciences Fibrosis medicine Animals biology Plant Extracts Myocardium Brain Toxoplasma gondii Heart Cell Biology medicine.disease biology.organism_classification Toxoplasmosis Toxoplasmosis Animal 030104 developmental biology Immunology Toxoplasma Encephalitis |
| Zdroj: | Pathology - Research and Practice. 213:50-57 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2016.11.003 |
| Popis: | In many cases, symptoms of toxoplasmosis are mistaken for the ones of other infectious diseases. Clinical signs are rare in immunocompetent people. However, when they arise, in the acute phase of infection, several organs are affected due to the rapid spread of tachyzoites through the bloodstream. In the present study, the reduction of tachyzoites in peripheral blood of mice of G72 (infected 72h after treatment) and G48 (infected 48h after treatment and treated three more times), when compared with IC (infected and non-treated), suggests protective effect exerted by Lycopodium clavatum. If on the one hand L. clavatum brought benefits, reducing parasitemia, on the other hand, the parasitism became exacerbated. Histopathological analysis demonstrated focal, multifocal and diffuse inflammatory infiltrates, ranging from absent, discreet, moderate to intense, in heart and encephalon of mice of NIC (non-infected and non-treated), IC, G48 and G72 groups, respectively. In the perivascular region and meninges, the injuries were enlarged. The presence of tachyzoites was demonstrated through immunohistochemical (IHC) assay in myocardium. Toxoplasma gondii induced increase of collagen fibers in myocardium of mice of G72 and G48 groups, compared with IC (p |
| Databáze: | OpenAIRE |
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