Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep
| Autor: | Anna Hauntoft Kongsted, Mette Olaf Nielsen, Lærke Johnsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Thyroid Hormones Endocrinology Diabetes and Metabolism Thyroid Gland Adipose tissue Biology Endocrinology Overnutrition Pregnancy Internal medicine medicine Animals Receptor Fetus Receptors Thyroid Hormone Sheep Thyroid Malnutrition medicine.disease medicine.anatomical_structure Prenatal Exposure Delayed Effects Female Hormone |
| Zdroj: | Johnsen, L, Kongsted, A H & Nielsen, M O 2013, ' Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep ', Journal of Endocrinology, vol. 216, no. 3, pp. 389-402 . https://doi.org/10.1530/JOE-12-0389 |
| Popis: | Mounting evidence led us to hypothesize that i) function of the thyroid hormone (TH) axis can be programed by late gestation undernutrition (LG-UN) and ii) early-postnatal-life overnutrition (EL-ON) exacerbates the fetal impacts on TH axis function. In a 2×2 factorial experiment, 21 twin-bearing sheep were fed one of two diets during late gestation: NORM (fulfilling energy and protein requirements) or LOW (50% of NORM). From day 3 to 6 months after birth (around puberty), the twin lambs were assigned to each their diet: conventional (CONV) or high-carbohydrate, high-fat, where after half the lambs were killed. Remaining sheep (exclusively females) were fed the same moderate diet until 2 years of age (young adults). At 6 months and 2 years of age, fasting challenges were conducted and target tissues were collected at autopsy. LG-UN caused adult hyperthyroidism associated with increased thyroid expression of genes regulating TH synthesis and deiodination. In one or more of the target tissues, liver, cardiac muscle, and longissimus dorsi muscle, gene expressions were increased by LG-UN for TH receptors (THRAandTHRB) and deiodinases but were decreased in visceral and subcutaneous adipose tissues. EL-ON increased TH levels in adolescent lambs, but this was reversed after diet correction and not evident in adulthood. We conclude that LG-UN programed TH axis function at the secretory level and differentially in target tissues, which was increasingly manifested with age. Differential TH signaling in adipose vs other tissues may be part of a mechanism whereby fetal malnutrition can predispose for obesity and other metabolic disorders. |
| Databáze: | OpenAIRE |
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