Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window

Autor:	Ling Pan, Wei-dong Tang, Ke Wang, Qi-feng Fang, Meng-ru Liu, Zhan-xun Wu, Yi Wang, Sun-liang Cui, Gang Hu, Ting-jun Hou, Wei-wei Hu, Zhong Chen, Xiang-nan Zhang
Rok vydání:	2021
Předmět:	Pharmacology Inflammasomes Caspase 1 General Medicine Cerebral Infarction Brain Ischemia Stroke Mice Inbred C57BL Mice Disease Models Animal Brain Injuries Animals Pharmacology (medical) Microglia Ischemic Stroke
Zdroj:	Acta pharmacologica Sinica. 43(11)
ISSN:	1745-7254
Popis:	Progressive ischemic stroke (PIS) is featured by progressive neurological dysfunction after ischemia. Ischemia-evoked neuroinflammation is implicated in the progressive brain injury after cerebral ischemia, while Caspase-1, an active component of inflammasome, exaggerates ischemic brain injury. Current Caspase-1 inhibitors are inadequate in safety and druggability. Here, we investigated the efficacy of CZL80, a novel Caspase-1 inhibitor, in mice with PIS. Mice and Caspase-1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc9f21876f2c7508e7d8261650467e8 https://pubmed.ncbi.nlm.nih.gov/35501362 Zobrazit plný text záznamu Full text from SpringerLink