Propensity score analysis confirms the independent effect of parenteral nutrition on the risk of central venous catheter-related bloodstream infection in oncological patients
| Autor: | Abdoulaye Touré, Cécile Chambrier, Catherine Lombard-Bohas, René Ecochard, Philippe Vanhems, J. C. Souquet |
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| Přispěvatelé: | Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Fresenius-Kabi France Society, Hospices Civils de Lyon |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Propensity score medicine.medical_treatment [SDV]Life Sciences [q-bio] Digestive System Neoplasms Critical Care and Intensive Care Medicine Logistic regression 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Central Venous Catheters Humans Prospective Studies 030212 general & internal medicine Risk factor Intensive care medicine Aged Proportional Hazards Models Nutrition and Dietetics Adjustment Cancer Performance status Proportional hazards model business.industry Middle Aged Parenteral nutrition 3. Good health Logistic Models Nonrandomised study Catheter-Related Infections 030220 oncology & carcinogenesis Propensity score matching FOLFIRI Female Parenteral Nutrition Total Catheter-related infection business Central venous catheter |
| Zdroj: | Clinical Nutrition Clinical Nutrition, 2013, 32 (6), pp.1050--4. ⟨10.1016/j.clnu.2012.12.006⟩ |
| DOI: | 10.1016/j.clnu.2012.12.006⟩ |
| Popis: | Summary Background & aims Parenteral nutrition is known as a high-risk factor for central venous catheter-related bloodstream infection (CVC-RBSI) in cancer patients. Owing to ethical and technical problems, the studies in the literature have nonrandomized designs and are therefore often confounded by biases. We performed a propensity score analysis to estimate the effect of parenteral nutrition on CVC-RBSI in digestive cancer patients who underwent chemotherapy. Methods Data were collected prospectively. A logistic regression model was used to calculate a propensity score, which was the probability of receiving parenteral nutrition. Kaplan–Meier survival and Cox regression model were used to estimate the effect of the parenteral nutrition on CVC-RBSI after adjustment for the propensity score. Results Before the propensity score analysis, the differences between patients with (n = 113) and without (n = 312) parenteral nutrition were identified including: male gender, body weight, weight loss, performance status, location of primary cancer, FOLFIRI, and previous long-term corticotherapy. After propensity score stratification, all of the covariates were balanced within each stratum. After adjustment, patients with parenteral nutrition were at a higher risk for CVC-RBSI. Conclusion By using the propensity score analysis, this study confirmed that parenteral nutrition was an independent risk factor for CVC-RBSI in digestive cancer patients. |
| Databáze: | OpenAIRE |
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