Liver response to low-hexachlorobenzene exposure in protein- or energy-restricted rats
| Autor: | A.Y.O. Angeleli, M.A.M. Rodrigues, M. Sanchez-Negrette, J.L.V. de Camargo, M.S. Mantovani, Léa Silvia Sant'Ana, M.R. Montenegro |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Adult male Administration Oral Adipose tissue Biology Toxicology chemistry.chemical_compound Internal medicine Hexachlorobenzene medicine Paralysis Animals Tissue Distribution Restricted diet Organ weight Body Weight Rats Inbred Strains Organ Size General Medicine Rats Endocrinology Liver chemistry Toxicity Zoxazolamine Dietary Proteins medicine.symptom Energy Intake Food Science medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 29:757-764 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/0278-6915(91)90184-9 |
| Popis: | The individual effects of protein deficiency and energy restriction on liver response to low-hexachlorobenzene (HCB) exposure were investigated in adult male Wistar rats. In rats fed either the low-protein or control diet, the only effect caused by HCB was a decrease in paralysis time following an ip injection of zoxazolamine. This decrease was similar for both groups. In the animals subjected to energy restriction, HCB induced a greater decrease in paralysis time, an increase in the size of centrilobular hepatocytes, a lower liver DNA content and an increased concentration of HCB in the adipose tissue, compared with the control and protein-deficient groups. Our data suggest that energy restriction increases liver response to HCB, while protein deficiency does not impair the hepatic reaction to small doses of HCB exposure. |
| Databáze: | OpenAIRE |
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