Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients
| Autor: | Dirk Rades, Rainer Schulte, Peter Hoskin, Rita Engenhart-Cabilic, Theo Veninga, Lukas J.A. Stalpers, Hiba Basic, Steven E. Schild |
|---|---|
| Přispěvatelé: | Cancer Center Amsterdam, Radiotherapy |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Urology Metastasis Cohort Studies Central nervous system disease Spinal cord compression Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Spinal Cord Neoplasms Lung cancer Survival analysis Aged Retrospective Studies Aged 80 and over business.industry Radiotherapy Dosage Middle Aged medicine.disease Survival Analysis Surgery Radiation therapy Regimen Treatment Outcome Oncology Female business Spinal Cord Compression |
| Zdroj: | European journal of cancer (Oxford, England, 42(8), 1052-1056. Elsevier Limited |
| ISSN: | 0959-8049 |
| Popis: | Many different schedules are used world wide for radiotherapy (RT) of metastatic spinal cord compression (MSCC). Non-small cell lung cancer (NSCLC) patients have an extraordinarily poor survival prognosis and would benefit from a short overall treatment time. This retrospective study compares short-course RT (1 x 8 Gy/1 day, 5 x 4 Gy/1 week) and long-course RT (10 x 3 Gy/2 weeks, 15 x 2.5 Gy/3 weeks, 20 x 2 Gy/4 weeks) for functional outcome in 252 NSCLC patients developing MSCC. Improvement of motor function occurred in 14% of patients, no change in 54%, and deterioration in 32%. Functional outcome was affected by the time of developing motor deficits before RT (>14 days better than 1-7 days and 8-14 days, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect