The Effect of Unfocused Extracorporeal Shock Wave Therapy on Bone Defect Healing in Diabetics
| Autor: | Mehmet Cihan Bereket, Mehmet Emin Önger, Enes Özkan, Ahmet Veysel Polat |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2018 |
| Předmět: |
Extracorporeal Shockwave Therapy
Male medicine.medical_specialty Extracorporeal shock wave therapy medicine.medical_treatment Urology Connective tissue Diabetes Mellitus Experimental Neovascularization 03 medical and health sciences 0302 clinical medicine extracorporeal shock wave Mandibular Fractures Hounsfield scale Diabetes mellitus rat unfocused medicine Animals Rats Wistar Wound Healing 030222 orthopedics business.industry Bone defect 030206 dentistry General Medicine medicine.disease Rats Disease Models Animal medicine.anatomical_structure Otorhinolaryngology Extracorporeal shockwave therapy diabetes mellitus Surgery Analysis of variance medicine.symptom business |
| Zdroj: | Journal of Craniofacial Surgery. 29:1081-1086 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/scs.0000000000004303 |
| Popis: | Tiemeier, Henning/0000-0002-4395-1397 WOS: 000434304300098 PubMed: 29461364 Aim: The purpose of this study was to evaluate the effect of the unfocused extracorporeal shock wave therapy (ESWT) on healing of mandible ramus defects in diabetic rats. Material and method: Forty male Wistar albino rats were used in the experiment. All animals were randomly divided into 2 main groups, nondiabetic and diabetic. Critical-sized defects were created on ramus in all rats. ESWT was performed to half of rats in each group at 3 sessions after surgery. Animals were euthanized at either fourth or eighth week. Stereological and radiologic examination was performed. Data were statistically analyzed by one-way variance analysis and Tukey post-hoc test. Results: Hounsfield Unit values were higher in D-E+ group than D-E- group in both 8-week and 4-week groups (P>0.05). In both 4-week and 8-week diabetic groups, higher value was observed when compared with nondiabetic groups (P>0.05). According to stereological results, in 4-week groups, there was a higher new bone, connective tissue, and neovascularization volume in D-E- group than D-E+ group and in D+E- group than D+E+ group. These results are similar for the 8-week groups except NV volume. Conclusion: It was found that ESWT application has no positive effect on the healing of critical-sized bone defects in nondiabetics whereas promising effects in diabetics were observed. Project Management Office Coordinatorship of Ondokuz Mayis UniversityOndokuz Mayis University [PYO.-DIS.1904.12.006] This experimental study was supported by Project Management Office Coordinatorship of Ondokuz Mayis University with PYO.-DIS.1904.12.006 project code. |
| Databáze: | OpenAIRE |
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