Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV
| Autor: | Shoichi Nakanishi, Tokutarou Minamizato, Kei Sakamoto, Ken-ichi Katsube, Akira Yamaguchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Cell signaling Notch Dentistry(all) Osteoblast Mesenchymal stem cell Notch signaling pathway Anatomy Biology Bone morphogenetic protein Cell biology RUNX2 lcsh:RK1-715 medicine.anatomical_structure CCN3/NOV lcsh:Dentistry embryonic structures medicine BMP Progenitor cell General Dentistry Transcription factor |
| Zdroj: | Japanese Dental Science Review, Vol 44, Iss 1, Pp 48-56 (2008) |
| ISSN: | 1882-7616 |
| Popis: | Summary Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes. Various hormones and cytokines regulate osteoblast differentiation of mesenchymal progenitors to osteoblasts. Among these, bone morphogenetic proteins (BMPs) are the most potent inducers and stimulators of osteoblast differentiation: BMPs not only stimulate osteoprogenitors to differentiate into mature osteoblasts but also induce non-osteogenic cells to differentiate into osteoblast lineage cells. BMPs are important local factors that regulate Runx2, which is an essential transcription factor for osteoblast differentiation. The Notch signaling pathway is involved in a variety of cellular function, including cell proliferation, differentiation and apoptosis. Notch signaling has a dual effect on osteoblast differentiation. In terms of stimulation, functional Notch signaling is essential not only for BMP-2-induced osteoblast differentiation but also for BMP signaling itself. CCN3/NOV, a member of the CCN family of proteins, exerts inhibitory effects on BMP-2-induced osteoblast differentiation via its involvement in the BMP and Notch signaling pathways. Thus, osteoblast differentiation is critically regulated by the intimate interaction of various signaling molecules including BMP, Notch and CCN3/NOV. |
| Databáze: | OpenAIRE |
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