Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need
| Autor: | Daniel Hartman, Sarah Garner, P Saltonstall, M. M. Lumpkin, Mark R. Trusheim, Gigi Hirsch, Robyn Lim, Harry P. Selker, Katherine E. Isaacs, M Bala, E Cobbs, E Pezalla, Kenneth A. Oye |
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| Přispěvatelé: | Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Center for Biomedical Innovation, Sloan School of Management, Hirsch, Paula, Trusheim, Mark, Garner, Steven K., Isaacs, Kate W., Oye, Kenneth A, Selker, Harry |
| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
Process management business.industry Public policy Business process reengineering Bioinformatics 030226 pharmacology & pharmacy Structuring Maturity (finance) 03 medical and health sciences 0302 clinical medicine Sustainability Medicine Pharmacology (medical) 030212 general & internal medicine Product (category theory) business Pharmaceutical industry Pace |
| Zdroj: | Wiley |
| Popis: | The current system of biomedical innovation is unable to keep pace with scientific advancements. We propose to address this gap by reengineering innovation processes to accelerate reliable delivery of products that address unmet medical needs. Adaptive biomedical innovation (ABI) provides an integrative, strategic approach for process innovation. Although the term “ABI” is new, it encompasses fragmented “tools” that have been developed across the global pharmaceutical industry, and could accelerate the evolution of the system through more coordinated application. ABI involves bringing stakeholders together to set shared objectives, foster trust, structure decision-making, and manage expectations through rapid-cycle feedback loops that maximize product knowledge and reduce uncertainty in a continuous, adaptive, and sustainable learning healthcare system. Adaptive decision-making, a core element of ABI, provides a framework for structuring decision-making designed to manage two types of uncertainty – the maturity of scientific and clinical knowledge, and the behaviors of other critical stakeholders. Ewing Marion Kauffman Foundation Alfred P. Sloan Foundation Massachusetts Technology Collaborative Robert Wood Johnson Foundation |
| Databáze: | OpenAIRE |
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