Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity
| Autor: | Iswari Setijaningsih, Pieter J. J. Sauer, Sudarto Ronoatmodjo, J Edy Siswanto, Ag Soemantri, Rita S. Sitorus |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MISSENSE MUTATIONS
Pediatrics medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities genetic structures Population VARIANTS rop polymorphism Pathogenesis 03 medical and health sciences Exon 0302 clinical medicine pcr 030225 pediatrics medicine Missense mutation DNA sequencing education X chromosome POPULATION education.field_of_study IDENTIFICATION business.industry Retinopathy of prematurity medicine.disease eye diseases Ophthalmology 030221 ophthalmology & optometry norrie disease gene NDP GENE FRIZZLED-4 Original Article Norrie disease Gene polymorphism mutation business |
| Zdroj: | Bmj open ophthalmology, 4(1):000211. BMJ PUBLISHING GROUP BMJ Open Ophthalmology |
| ISSN: | 2397-3269 |
| Popis: | ObjectiveRetinopathy of prematurity (ROP) is a major cause of blindness in newborn infants, which also occurs in low-income and middle-income countries. Why ROP progresses in some infants while it regresses in others is still presently unknown. Studies suggest that genetic factors might be involved. Mutations in the Norrie disease (ND) gene are suspected to be related to advanced ROP development. Indonesia is a country with relatively high incidence of ROP, yet the role of these genetic factors in the pathogenesis of ROP cases is still unknown. The study aimed to investigate the presence of mutations in ND on the X chromosome in infants with both non-advanced and advanced ROP in Indonesia.Methods and AnalysisThis is a case–control study of polymorphisms in six variants within the ND gene in exon 3, C597A, L108P, R121W, A105T, V60E and C110G, in preterm newborn infants in four major hospitals in Greater Jakarta, Indonesia.ResultsWe included 162 preterm newborn infants. ROP was diagnosed in 83 infants, and 79 infants served as controls. Among those with ROP, 57 infants had type 2, while others had type 1. We did not find any gene polymorphisms in any of the infants with ROP nor in the control group.ConclusionWe conclude that it is very unlikely that the six polymorphisms in exon 3 of the ND gene studied in this paper are involved in the development or progression of ROP in preterm infants in our population sample in Indonesia. |
| Databáze: | OpenAIRE |
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