Beryllium-induced ultrastructural changes in intact and regenerating liver
| Autor: | Michael W. Lieberman, Peter J. Goldblatt, Hanspeter R. Witschi |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Nucleolus Kupffer Cells Golgi Apparatus Mitosis Mitochondria Liver Partial hepatectomy Biology Bone canaliculus Endoplasmic Reticulum Liver necrosis Male rats medicine Environmental Chemistry Animals General Environmental Science Public Health Environmental and Occupational Health Liver Regeneration Rats Microscopy Electron Vacuolization Liver Ultrastructure Beryllium Chemical and Drug Induced Liver Injury Lysosomes Ribosomes |
| Zdroj: | Archives of environmental health. 26(1) |
| ISSN: | 0003-9896 |
| Popis: | Intact or partially hepatectomized male rats were given intravenous aqueous BeSO4 · 4H2O. Light microscope studies of partially hepatectomized animals examined at 6, 12, 24, and 48 hours after injection of 15, 30, or 60μmols BeSO4 per kilogram or given 30/μmols BeSO4 per kilogram 8, 12, and 22 hours after partial hepatectomy and killed at 28 hours, revealed liver necrosis in animals surviving 48 hours, and abolition of mitoses in animals treated 20 or 16 hours before death. Ultrastructural alterations in both intact and partially hepatectomized animals examined 24 hours following Be injection included vacuolization and dense deposits in lysosomes, loss of fibrils and appearance of dense plaques in some nucleoli, and distortion of bile canaliculi. The lysosomal changes and inhibition of mitosis correlate well with previous biochemical studies. |
| Databáze: | OpenAIRE |
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