Membranous nephropathy with solitary polyclonal IgA deposition: A case report and literature review
| Autor: | Hideki Wakui, Masato Sawamura, Atsushi Komatsuda, Hajime Kaga, Kensuke Joh, Ayano Saito, Naoto Takahashi, Tadashi Yasuda |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty rare disease Case Report law.invention Membranous nephropathy law Microscopy medicine biology medicine.diagnostic_test business.industry solitary polyclonal IgA deposition membranous nephropathy medicine.disease Nephrology Polyclonal antibodies biology.protein Prednisolone Renal biopsy Geriatrics and Gerontology Electron microscope business Nephrotic syndrome medicine.drug Rare disease |
| Zdroj: | Clinical Nephrology. Case Studies |
| ISSN: | 2196-5293 |
| Popis: | A 60-year-old man presented with nephrotic syndrome (NS). Light microscopy of renal biopsy specimens showed minor glomerular abnormalities, while immunofluorescence microscopy revealed solitary polyclonal granular IgA deposition along the glomerular capillary walls. Electron microscopy showed small amounts of electron-dense deposits in the subepithelial area, but not in the mesangial area. In this patient, apparent underlying disease was not found during the 3-year follow-up, and low-dose prednisolone was effective in the treatment of NS. To our knowledge, there is only one case report of membranous nephropathy with clinicopathological features similar to our case. |
| Databáze: | OpenAIRE |
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