Pulmonary alterations in patients with chronic HCV infection
| Autor: | H. Erturk, A. Erturk, Adile Berna Dursun, H. Bozkaya, A.N. Tokgonul, N. Capan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Thorax medicine.medical_specialty Pathology Vital capacity Tuberculosis Respiratory Tract Diseases Gastroenterology Virus Pulmonary function testing Internal medicine medicine Humans Prospective Studies Prospective cohort study Lung Aged Carbon Monoxide Hepatology business.industry Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Respiratory Function Tests medicine.anatomical_structure Female Tomography X-Ray Computed business |
| Zdroj: | Digestive and Liver Disease. 38:673-676 |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/j.dld.2006.05.013 |
| Popis: | Background Chronic hepatitis C virus infection has been reported in association with several extrahepatic manifestations. Included in this list is interstitial lung involvement. Aims The aim of the present study was to evaluate pulmonary alterations in patients with chronic hepatitis C virus infection. Patients Twenty-one patients with chronic hepatitis C virus infection were enrolled into a prospective study. One patient has been excluded because of underlying tuberculosis. Methods All patients underwent pulmonary function tests, diffusion capacity for carbon monoxide and high-resolution computed tomography of the chest. Results Forced vital capacity, forced expiratory volume in first second/forced vital capacity and forced expiratory volume in first second values were reduced to less than 80% of predicted values in 3, 11 and 5 patients, respectively. Diffusion capacity for carbon monoxide was low in 12 patients (60%), 8 of whom had simultaneous decrease in diffusion capacity for carbon monoxide/VA values. Thorax high-resolution computed tomography revealed abnormal findings in eight patients (40%). Fifteen patients with chronic hepatitis C virus infection (75%) had at least one pulmonary alteration as evidenced by abnormal pulmonary function tests, diffusion capacity for carbon monoxide and/or high-resolution computed tomography results. Conclusion In spite of a limited study population, these findings may implicate that pulmonary manifestations of chronic hepatitis C virus infection are frequently underdiagnosed. |
| Databáze: | OpenAIRE |
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