Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis
| Autor: | Bernd Zur, Alexander Semmler, Michael Linnebank, Andreas Grigull, Henk J. Blom, Thomas Klockgether, Yvo M. Smulders, Susanna Moskau, Birgit Stoffel-Wagner, Susan Farmand |
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| Přispěvatelé: | Internal medicine, Clinical chemistry, EMGO - Lifestyle, overweight and diabetes, ICaR - Ischemia and repair, University of Zurich, Linnebank, M |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Lipoproteins Medicine (miscellaneous) 610 Medicine & health lcsh:TX341-641 chemistry.chemical_compound Folic Acid High-density lipoprotein Internal medicine medicine Humans Vitamin B12 lcsh:RC620-627 Retrospective Studies Nutrition and Dietetics Cholesterol business.industry Research Cholesterol HDL 2701 Medicine (miscellaneous) Cholesterol LDL 10040 Clinic for Neurology lcsh:Nutritional diseases. Deficiency diseases Vitamin B 12 Cross-Sectional Studies Endocrinology chemistry Quartile Low-density lipoprotein 2916 Nutrition and Dietetics Population study lipids (amino acids peptides and proteins) Female business lcsh:Nutrition. Foods and food supply Lipoprotein |
| Zdroj: | Nutrition Journal Nutrition Journal, Vol 9, Iss 1, p 31 (2010) Nutrition Journal, 9:31. BioMed Central Semmler, A, Moskau, S, Grigull, A, Farmand, S, Klockgether, T, Smulders, Y M, Blom, H J, Zur, B, Stoffel-Wagner, B & Linnebank, M 2010, ' Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis ', Nutrition Journal, vol. 9, 31 . https://doi.org/10.1186/1475-2891-9-31 |
| ISSN: | 1475-2891 |
| DOI: | 10.1186/1475-2891-9-31 |
| Popis: | Background Several studies demonstrated an association of homocysteine plasma levels and the plasma lipoprotein profile. This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile. Methods In a retrospective single center approach, we analyzed the laboratory database (2003-2006) of the University Hospital Bonn, Germany, including 1743 individuals, in whom vitamin B12, folate and at least one lipoprotein parameter had been determined by linear multilogistic regression. Results Higher folate serum levels were associated with lower serum levels of low density lipoprotein cholesterol (LDL-C; Beta = -0.164; p < 0.001), higher levels of high density lipoprotein cholesterol (HDL-C; Beta = 0.094; p = 0.021 for trend) and a lower LDL-C-C/HDL-C-ratio (Beta = -0.210; p < 0.001). Using ANOVA, we additionally compared the individuals of the highest with those of the lowest quartile of folate. Individuals of the highest folate quartile had higher levels of HDL-C (1.42 ± 0.44 mmol/l vs. 1.26 ± 0.47 mmol/l; p = 0.005), lower levels of LDL-C (3.21 ± 1.04 mmol/l vs. 3.67 ± 1.10 mmol/l; p = 0.001) and a lower LDL-C/HDL-C- ratio (2.47 ± 1.18 vs. 3.77 ± 5.29; p = 0.002). Vitamin B12 was not associated with the lipoprotein profile. Conclusion In our study sample, high folate levels were associated with a favorable lipoprotein profile. A reconfirmation of these results in a different study population with a well defined status of health, diet and medication is warranted. |
| Databáze: | OpenAIRE |
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