Antiglycation potential and antioxidant activity of genipap (Genipa americana L.) in oxidative stress mediated by hydrogen peroxide on cell culture

Autor: Aline Costa Santos, Felipe Akihiro Melo Otsuka, Rodrigo Brito Santos, Danielle de Jesus Trindade, Humberto Reis Matos
Rok vydání: 2022
Předmět:
DOI: 10.6084/m9.figshare.21076940
Popis: Genipa americana L. is a plant widely used by folk medicine for the prevention and as an aid in the treatment of various diseases. In this work, we evaluated the anti-glycant and antioxidant activities of genipap fruit juice, as well as the influence of different temperatures (−6 °C and −80 °C) on the preservation of phenolic compounds. Purified extract from G. americana showed anti-glycant activity reducing the formation of fructosamine by up to 53% and recovered viability of cells under oxidative stress induced by H2O2. HPLC/UV-Vis analysis identified cinnamic acid as a bioactive substance and possibly responsible for the biological activities described above. Taken together, these results indicate that G. americana is a rich source of cinnamic acid with appreciable antioxidant and anti-glycant potential.
Databáze: OpenAIRE