Endogenous phospholipase A2 inhibitors in snakes: a brief overview
| Autor: | Consuelo Latorre Fortes-Dias, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Patrícia Cota Campos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Phospholipase A2 inhibitor Myotoxin Endogeny Natural resistance Phospholipase Toxicology 03 medical and health sciences Phospholipase A2 lcsh:RA1190-1270 lcsh:Zoology PLA2 inhibitor lcsh:QL1-991 lcsh:Toxicology. Poisons 030102 biochemistry & molecular biology biology Snakes Inhibitor protein biology.organism_classification Snake blood Bothrops alternatus 030104 developmental biology Infectious Diseases Biochemistry Immunology biology.protein Animal Science and Zoology Parasitology Antibody |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2017) Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 22, Article number: 37, Published: 19 JAN 2017 |
| Popis: | The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized. |
| Databáze: | OpenAIRE |
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