Clinical Picture and Risk Factors of Severe Respiratory Symptoms in COVID-19 in Children

Autor:	Jowita Rosada-Kurasińska, Magdalena Figlerowicz, Zuzanna Lewandowska, Katarzyna Mazur-Melewska, Agnieszka Cwalińska, Alicja Bartkowska-Śniatkowska, Katarzyna Jończyk-Potoczna, Karol Lubarski, Kamil Faltin, Paweł Małecki, Anna Mania
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Adolescent medicine.medical_treatment Respiratory System Comorbidity comorbidities Microbiology COVID-19 children respiratory symptoms imaging abnormalities lactate dehydrogenase creatinine kinase Severity of Illness Index Article Risk Factors Virology Intensive care Oxygen therapy Internal medicine medicine Humans Respiratory system Child medicine.diagnostic_test business.industry SARS-CoV-2 Area under the curve Infant Odds ratio Auscultation Respiration Artificial QR1-502 Confidence interval Hospitalization Infectious Diseases Child Preschool Cohort Female business
Zdroj:	Viruses Viruses; Volume 13; Issue 12; Pages: 2366 Viruses, Vol 13, Iss 2366, p 2366 (2021)
ISSN:	1999-4915
Popis:	Children with COVID-19 develop moderate symptoms in most cases. Thus, a proportion of children requires hospital admission. The study aimed to assess the history, clinical and laboratory parameters in children with COVID-19 concerning the severity of respiratory symptoms. The study included 332 children (median age 57 months) with COVID-19. History data, clinical findings, laboratory parameters, treatment, and outcome, were evaluated. Children were compared in the groups that varied in the severity of symptoms of respiratory tract involvement. Children who required oxygen therapy represented 8.73%, and intensive care 1.5% of the whole cohort. Comorbidities were present in 126 patients (37.95%). Factors increasing the risk of oxygen therapy included comorbidities (odds ratio (OR) = 92.39; 95% confidence interval (95% CI) = (4.19; 2036.90); p < 0.00001), dyspnea (OR = 45.81; 95% CI (4.05; 518.21); p < 0.00001), auscultation abnormalities (OR = 34.33; 95% CI (2.59; 454.64); p < 0.00001). Lactate dehydrogenase (LDH) > 280 IU/L and creatinine kinase > 192 IU/L were parameters with a good area under the curve (0.804-LDH) and a positive predictive value (42.9%-CK). The clinical course of COVID-19 was mild to moderate in most patients. Children with comorbidities, dyspnea, or abnormalities on auscultation are at risk of oxygen therapy. Laboratory parameters potentially useful in patients evaluated for the severe course are LDH > 200 IU/L and CK > 192 IU/L.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb9e3b0129047f8df20c706b39be37e https://pubmed.ncbi.nlm.nih.gov/34960635 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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