Curcumin and cancer; are long non-coding RNAs missing link?
| Autor: | Saeed Mohammadian Haftcheshmeh, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Arezoo Gowhari Shabgah, Naseh Pahlavani, Seyedeh Shabnam Mazloumi Kiapey, Fatemeh Ezzatifar, Sudiyeh Hejri Zarifi, Davood Soleimani |
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| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
Curcumin business.industry Biophysics Wnt signaling pathway Cancer Antineoplastic Agents medicine.disease Metastasis Phosphatidylinositol 3-Kinases chemistry.chemical_compound chemistry Neoplasms Cancer cell Cancer research Humans Medicine RNA Long Noncoding business Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway |
| Zdroj: | Progress in Biophysics and Molecular Biology. 164:63-71 |
| ISSN: | 0079-6107 |
| DOI: | 10.1016/j.pbiomolbio.2021.04.001 |
| Popis: | Despite significant signs of progress in cancer treatment over the past decade, either cancer prevalence or mortality continuously grow worldwide. Current anti-cancer agents show insignificant effectiveness, followed by serious side effects. It is important to find new, highly efficient pharmacological agents to increase cancer patients' clinical outcomes. Curcumin, a polyphenolic compound, has gained growing attention because of its anti-cancer properties. Curcumin can hinder the development, migration, and metastasis of cancer cells. The anti-cancer effects of curcumin are principally attributed to the regulation of several cellular signaling pathways, including MAPK/PI3K/Akt, Wnt/β-catenin, JAK/STAT, and NF-ĸB signaling pathways. Furthermore, curcumin can affect the expression and function of tumor-suppressive and oncogenic long non-coding RNAs (lncRNAs). In this study, we briefly reviewed the modulatory effect of curcumin on dysregulated tumor-supportive and tumor-suppressive lncRNAs in several cancers. It is hoped that a better understanding of curcumin's anti-cancer properties would pave the way for the development of a therapeutic approach in cancer. |
| Databáze: | OpenAIRE |
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