Microvascular function measurement in mice: From large to small
| Autor: | Ichiro Matsunari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Technetium Tc 99m Sestamibi
Tomography Emission-Computed Single-Photon business.industry Myocardium Blood flow 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences Mice 0302 clinical medicine Blood volume measurement Medicine Animals Humans Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine business Neuroscience Function (biology) |
| Zdroj: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 28(6) |
| ISSN: | 1532-6551 |
| Popis: | There is a growing body of interest in cardiac microvascular function because it plays an important role in various cardiac disease conditions. Therefore, efforts have been made to develop non-invasive techniques to measure microvascular function. In this issue of the journal, Guerraty et al developed a micro-SPECT-based approach to assess microvascular function in in vivo mice. They applied two independent approaches to measure microvascular function: (1) myocardial blood flow measurement using 99mTc-sestamibi as a flow tracer and (2) intramyocardial blood volume measurement using 99mTc-red blood cells. Although there are issues to be addressed, they provided an important framework for non-invasive assessment of microvascular function in mice, where a number of disease models are readily available. Thus, their approaches are encouraging for facilitating better understanding of pathophysiology underlying microvascular disease models, and thereby the development of therapeutic options in future. |
| Databáze: | OpenAIRE |
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