Bacterial Toxins Active against Mosquitoes: Mode of Action and Resistance
| Autor: | Tatiana Maria Teodoro Rezende, Tatiany Patrícia Romão, Mario Soberón, Alejandra Bravo, Maria Helena Neves Lobo Silva-Filha, Heverly Suzany Gouveia de Menezes, Nathaly Alexandre do Nascimento, Karine da Silva Carvalho |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Mosquito Control Health Toxicology and Mutagenesis 030231 tropical medicine Bacterial Toxins Bacillus thuringiensis receptors Review Biology binary toxin Toxicology medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine medicine cry toxin Animals Cyt toxin Mode of action Receptor Pest Control Biological Bacillaceae Pore-forming toxin Toxin Lysinibacillus sphaericus fungi Midgut Bti biology.organism_classification 030104 developmental biology Culicidae Mechanism of action Medicine medicine.symptom Bacteria |
| Zdroj: | Toxins, Vol 13, Iss 523, p 523 (2021) Toxins |
| ISSN: | 2072-6651 |
| Popis: | Larvicides based on the bacteria Bacillus thuringiensis svar. israelensis (Bti) and Lysinibacillus sphaericus are effective and environmentally safe compounds for the control of dipteran insects of medical importance. They produce crystals that display specific and potent insecticidal activity against larvae. Bti crystals are composed of multiple protoxins: three from the three-domain Cry type family, which bind to different cell receptors in the midgut, and one cytolytic (Cyt1Aa) protoxin that can insert itself into the cell membrane and act as surrogate receptor of the Cry toxins. Together, those toxins display a complex mode of action that shows a low risk of resistance selection. L. sphaericus crystals contain one major binary toxin that display an outstanding persistence in field conditions, which is superior to Bti. However, the action of the Bin toxin based on its interaction with a single receptor is vulnerable for resistance selection in insects. In this review we present the most recent data on the mode of action and synergism of these toxins, resistance issues, and examples of their use worldwide. Data reported in recent years improved our understanding of the mechanism of action of these toxins, showed that their combined use can enhance their activity and counteract resistance, and reinforced their relevance for mosquito control programs in the future years. |
| Databáze: | OpenAIRE |
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