Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors
| Autor: | Yoshihiko Usui, Takeshi Nagai, Daniel Diaz-Aguilar, Hiroshi Goto, Toshitaka Nagao, Shunichiro Ueda |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty genetic structures CD30 Biopsy Antigens CD19 Lymphoproliferative disorders Immunophenotyping Diagnosis Differential 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Orbital Diseases medicine Humans Aged Retrospective Studies medicine.diagnostic_test business.industry Interleukin-2 Receptor alpha Subunit hemic and immune systems MALT lymphoma Lymphoma B-Cell Marginal Zone General Medicine Middle Aged Flow Cytometry medicine.disease Immunohistochemistry Lymphoproliferative Disorders Lymphoma Ophthalmology 030104 developmental biology Immunoglobulin G 030220 oncology & carcinogenesis Orbital Neoplasms Female sense organs CD5 business |
| Zdroj: | Japanese Journal of Ophthalmology. 61:354-360 |
| ISSN: | 1613-2246 0021-5155 |
| DOI: | 10.1007/s10384-017-0513-1 |
| Popis: | To evaluate novel immunophenotypic profiles of patients with orbital lymphoproliferative tumors. From 2006 to 2014, surgical biopsies from consecutive patients with newly diagnosed orbital mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) were collected from Tokyo Medical University Hospital. A total of 44 tumors from 44 patients were analyzed, including 21 with orbital MALT lymphoma (11 men and 10 women, mean age 67.8 ± 13.4 years) and 23 with definitive IgG4-ROD (9 men and 14 women, mean age 60.5 ± 15.1 years). Patients with secondary orbital MALT lymphoma and MALT lymphoma with IgG4-ROD were excluded. All patients were immunocompetent Asian adults. Samples were analyzed by immunohistochemistry and flow cytometric analysis. Flow cytometry was performed with the following antibodies: CD3, CD4, CD5, CD8, CD10, CD19, CD20, CD23, CD25, CD30, CD34, and CD56 lambda and kappa chains. Expression of CD25 and CD19 was higher in patients with orbital MALT lymphoma compared to patients with IgG4-ROD (p |
| Databáze: | OpenAIRE |
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