Mitochondrial Dysfunction and Ovarian Aging
| Autor: | Emre Seli, Işıl Kasapoğlu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Infertility Aging medicine.medical_specialty Mitochondrial DNA Reproductive Techniques Assisted media_common.quotation_subject Physiology Fertility Biology Oogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Animals Humans Ovarian reserve media_common 030219 obstetrics & reproductive medicine Ovary medicine.disease Oocyte Mitochondria 030104 developmental biology medicine.anatomical_structure Ovarian dysfunction Female |
| Zdroj: | Endocrinology. 161 |
| ISSN: | 1945-7170 0013-7227 |
| Popis: | As women delay childbearing because of demographic and socioeconomic trends, reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent causes of infertility. Age-related decline in fertility is characterized by both quantitative and qualitative deterioration of the ovarian reserve. Importantly, disorders of aging are frequently associated with mitochondrial dysfunction, as are impaired oogenesis and embryogenesis. Ongoing research explores the role of mitochondrial dysfunction in ovarian aging, and potential ways to exploit mitochondrial mechanisms to slow down or reverse age-related changes in female gonads. |
| Databáze: | OpenAIRE |
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