Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons
| Autor: | James B. Priestley, Howard Eichenbaum, Jon W Rueckemann, Vittoria A. Smeglin, Aaron D. Garcia, Nick T. M. Robinson, Francesca A. Marino |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Time Factors media_common.quotation_subject Hippocampus Optogenetics Hippocampal formation Article 03 medical and health sciences 0302 clinical medicine Medial entorhinal cortex Memory Contrast (vision) Animals Entorhinal Cortex Theta Rhythm CA1 Region Hippocampal media_common Neurons General Neuroscience Grid cell Rats 030104 developmental biology Psychology Neuroscience 030217 neurology & neurosurgery Coding (social sciences) |
| Zdroj: | Neuron. 94(3) |
| ISSN: | 1097-4199 |
| Popis: | Recent studies have shown that hippocampal “time cells” code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inactivation of the medial entorhinal cortex on temporal, as well as spatial and object, coding by hippocampal CA1 neurons. Medial entorhinal inactivation produced a specific deficit in temporal coding in CA1 and resulted in significant impairment in memory across a temporal delay. In striking contrast, spatial and object coding remained intact. Further, we extended the scope of hippocampal phase precession to include object information relevant to memory and behavior. Overall, our work demonstrates that medial entorhinal activity plays an especially important role for CA1 in temporal coding and memory across time. |
| Databáze: | OpenAIRE |
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