Correlation between Cyclosporine Blood Levels and Area under Blood Concentration Time Curve in Iraqi Bone Marrow Transplant Patients Treated with Neoral® Oral Solution
| Autor: | Kawther F. Al-Tamimi, Duaa J. Al-Tamimi, Hassan M. Abass, Jaafar J. Ibraheem |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Bone marrow transplant medicine.medical_specialty AUC media_common.quotation_subject medicine.medical_treatment bone marrow transplant Iraqi patients Urology lcsh:RS1-441 Pharmaceutical Science biochemical changes 030204 cardiovascular system & hematology Organ transplantation lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Therapeutic index Blood concentration polycyclic compounds Medicine Dosing Adverse effect media_common business.industry Immunosuppressive drug cyclosporine blood concentrations adverse effects business 030215 immunology |
| Zdroj: | Scientia Pharmaceutica Volume 88 Issue 1 Scientia Pharmaceutica, Vol 88, Iss 1, p 12 (2020) |
| ISSN: | 2218-0532 |
| Popis: | Cyclosporine is a potent immunosuppressive drug. It has a narrow therapeutic index, and therefore the measurement of cyclosporine&rsquo s blood concentration is essential to obtain optimal therapy. Measurement of the area under the blood concentration-time curve (AUC) is reflective of total drug exposure. However, for organ transplant patients, the measurement of AUC involves many problems and difficulties. Thus, it is more clinically acceptable to use a single blood sample as a surrogate index of total drug exposure. Fifty-four adults bone marrow transplant Iraqi patients were given cyclosporine every 12 h as prophylaxis using Neoral® oral solution. Steady-state blood concentrations were monitored for each patient at zero time and then at 1, 2, 3, 4, 6, 8, 10, and at 12 h post-dosing. Cyclosporine blood levels were determined by using AXSYM automated immuno-analyzer which is a fluorescence polarization immunoassay (FPIA). The present investigation demonstrated the best correlation between C2 and the corresponding AUC0&ndash 4h and AUC0&ndash 12h compared to other concentrations. After two months of cyclosporine therapy, no unexpected biochemical changes and adverse effects were registered. It is concluded from this study that a single blood sample obtained at 2 h post-dosing (C2) and possibly at 3 h post dosing (C3) are ideal surrogate indexes for reflecting total drug exposure, and therefore may be used in clinical practice for predicting therapeutic and toxic effects of cyclosporine. |
| Databáze: | OpenAIRE |
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