Development and in-vitro characterization of an implantable flow sensing transducer for hydrocephalus
| Autor: | Damien Joss, Philippe Büchler, Herbert Keppner, T. Bardyn, Markus Lempen, J. Burger, Yanik Tardy, Stephan Braun, Daniel Müller, Andreas Hogg, Toralf Bork |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Transducers Flow (psychology) Biomedical Engineering Cerebrospinal Fluid Proteins Prostheses and Implants Calorimetry medicine.disease Cerebrospinal Fluid Shunts In vitro Volumetric flow rate Hydrocephalus Kinetics Viscosity Transducer Cerebrospinal fluid Calibration medicine Humans Telemetry Molecular Biology Artificial cerebrospinal fluid Biomedical engineering |
| Zdroj: | Bork, T; Hogg, A; Lempen, M; Müller, D; Joss, D; Bardyn, T; Büchler, P; Keppner, H; Braun, S; Tardy, Y; Burger, J (2010). Development and in-vitro characterization of an implantable flow sensing transducer for hydrocephalus. Biomedical microdevices, 12(4), pp. 607-18. Dordrecht: Springer US; http://www.springer-ny.com 10.1007/s10544-010-9413-6 |
| DOI: | 10.1007/s10544-010-9413-6 |
| Popis: | An implantable transducer for monitoring the flow of Cerebrospinal fluid (CSF) for the treatment of hydrocephalus has been developed which is based on measuring the heat dissipation of a local thermal source. The transducer uses passive telemetry at 13.56 MHz for power supply and read out of the measured flow rate. The in vitro performance of the transducer has been characterized using artificial Cerebrospinal Fluid (CSF) with increased protein concentration and artificial CSF with 10\% fresh blood. After fresh blood was added to the artificial CSF a reduction of flow rate has been observed in case that the sensitive surface of the flow sensor is close to the sedimented erythrocytes. An increase of flow rate has been observed in case that the sensitive surface is in contact with the remaining plasma/artificial CSF mix above the sediment which can be explained by an asymmetric flow profile caused by the sedimentation of erythrocythes having increased viscosity compared to artificial CSF. After removal of blood from artificial CSF, no drift could be observed in the transducer measurement which could be associated to a deposition of proteins at the sensitive surface walls of the packaged flow transducer. The flow sensor specification requirement of +-10\% for a flow range between 2 ml/h and 40 ml/h. could be confirmed at test conditions of 37 degrees C. |
| Databáze: | OpenAIRE |
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