Gut Microbiota Composition of Biliary Atresia Patients Before Kasai Portoenterostomy Associates With Long-term Outcome
| Autor: | A Kurilshikov, Daan B E van Wessel, Janneke L. M. Bruggink, Henkjan J. Verkade, Jan B F Hulscher, Mark Nomden, Hermie J. M. Harmsen, R. H. J. de Kleine |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Microbes in Health and Disease (MHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
MECHANISM
medicine.medical_specialty cholestatic liver disease Jaundice Portoenterostomy Hepatic biliary atresia Gut flora Total serum bilirubin Gastroenterology Biliary atresia Internal medicine Original Articles: Hepatology RNA Ribosomal 16S medicine Humans Feces Surgical approach gut-liver axis biology gut microbiota business.industry Infant biology.organism_classification medicine.disease Gastrointestinal Microbiome Bifidobacteriaceae Child Preschool clearance of jaundice Pediatrics Perinatology and Child Health Etiology medicine.symptom business Kasai portoenterostomy |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition Journal of Pediatric Gastroenterology and Nutrition, 73(4), 485-490. Lippincott Williams and Wilkins |
| ISSN: | 0277-2116 |
| Popis: | BACKGROUND AND AIMS: Biliary atresia (BA) is a cholestatic, fibro-obliterative cholangiopathy of unknown etiology. BA is primarily treated by a surgical approach, i.e. the Kasai portoenterostomy (KPE), to obtain clearance of jaundice (COJ). The gut microbiota (GM) composition has been associated with the course of several cholestatic liver diseases. It is largely unknown, however, whether GM composition associates with the outcome of KPE. We compared the GM composition of BA patients and controls and assessed if GM composition before KPE was related to COJ after KPE.METHODS: We compared feces of term born BA patients before KPE and controls (patients undergoing inguinal hernia repair) by 16S rRNA sequencing. Composition and alpha diversity of the GM were compared between BA and controls before KPE and after KPE, between patients with COJ vs. without COJ (total serum bilirubin RESULTS: Alpha diversity was comparable between BA (n = 12, age 1.6[1.3-1.8]mo) and controls (n = 6, age 2.0[1.4-2.1]mo; P = 0.22). Compared to controls, BA patients had lower abundances of Bifidobacteriaceae (β=-1.98, P CONCLUSIONS: The gut microbiota of biliary atresia patients prior to Kasai portoenterostomy associates with outcome, clearance of jaundice, suggestive of predictive and mechanistic roles of the gut microbiota composition in bile homeostasis. |
| Databáze: | OpenAIRE |
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