Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function

Autor: Mohamed Faouzi, Katarzyna Michaud, Sara Sabatasso, Marc Bollmann, Patrice Mangin, Nicolas Donzé, Marc Augsburger
Rok vydání: 2007
Předmět:
Myocardium/pathology
Peptide Fragments/metabolism
Male
Biological Markers/metabolism
Embolism
Myocardial Ischemia
Autopsy
Coronary Artery Disease
Natriuretic Peptide
Brain
Natriuretic peptide
Forensic Pathology
Aged
80 and over
Vitreous Body/metabolism
Cardiac ischemia
Age Factors
Pericardial fluid
Coronary ischemia
Organ Size
Middle Aged
Pericardium/metabolism
Cardiology
Female
Pericardium
hormones
hormone substitutes
and hormone antagonists
Cardiac function curve
Adult
medicine.medical_specialty
medicine.drug_class
Myocardial Ischemia/metabolism
Pathology and Forensic Medicine
Coronary Artery Disease/metabolism/pathology
Sex Factors
Internal medicine
Natriuretic Peptide
Brain/metabolism
medicine
Humans
Coronary Thrombosis/metabolism/pathology
cardiovascular diseases
Aged
business.industry
Coronary Thrombosis
Myocardium
ddc:614.1
medicine.disease
Peptide Fragments
Vitreous Body
Case-Control Studies
Coronary Artery Disease/metabolism
Coronary Artery Disease/pathology
Coronary Thrombosis/metabolism
Coronary Thrombosis/pathology
Logistic Models
Heart failure
Forensic autopsy
business
Biomarkers
Zdroj: International Journal of Legal Medicine, vol. 122, no. 5, pp. 415-420
International Journal of Legal Medicine, Vol. 122, No 5 (2008) pp. 415-420
ISSN: 0937-9827
Popis: Clinical biomarkers of cardiac function could also be monitored postmortem. Among the natriuretic peptides, the aminoterminal portion of pro-brain natriuretic peptide (NT-proBNP) appears to be a more reliable postmortem tool than the BNP, owing to its longer half-life and greater stability. In living persons, NT-proBNP is considered to be a marker of heart failure, and its level rises after cardiac ischemia. The goal of this study was first to evaluate the postmortem stability of NT-proBNP, then to measure the NT-proBNP levels in postmortem cases of heart failure related to coronary ischemia. The goal of this study was also to evaluate the correlations between different specimens collected at autopsy (e.g. blood, serum, vitreous humor and pericardial fluid). The study included 96 cases, which were classified into 4 groups according to the autopsy and histological findings. The NT-proBNP levels were significantly higher in individuals who had suffered from chronic cardiac ischemia, with or without acute coronary events, than in either control cases or those who had suffered from acute thromboembolism or acute rupture of a plaque without chronic cardiac ischemia. The highest levels were registered in individuals who had suffered from acute coronary thromboembolism in association with chronic coronary ischemia. Good correlations in the NT-proBNP levels for the different specimens were observed between samples of femoral blood, serum, and pericardial fluid. Our data indicated that postmortem measurements of NT-proBNP are reliable and compatible with clinical findings.
Databáze: OpenAIRE
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