Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women
| Autor: | Puan Suthipinittharm, Shabbar Jaffar, Sylvie Deslandes, Bussakorn Mahakkanukrauh, NJ Robinson, Sukhum Jiamton, Frances M. Cowan, David Brown, Heiner Grosskurth, Kathryn Chu, Jacques Pépin, Pongsakdi Chaisilwattana, Ruengpung Suttent, Eric Frost |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Sexually transmitted disease medicine.medical_specialty Herpesvirus 2 Human viruses HIV Infections Semen Cervix Uteri Dermatology Antibodies Viral Hospitals Urban Acquired immunodeficiency syndrome (AIDS) medicine Humans Pharmacology (medical) Sex organ Prospective Studies Herpes Genitalis Ulcer Gynecology business.industry Public Health Environmental and Occupational Health Middle Aged Viral Load Thailand medicine.disease Infectious Diseases medicine.anatomical_structure Virus Diseases Carrier State Vagina Immunology HIV-1 Female Disease Susceptibility Viral disease business Viral load |
| Zdroj: | International Journal of STD & AIDS. 17:681-686 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1258/095646206780071108 |
| Popis: | We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions. |
| Databáze: | OpenAIRE |
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