High SARS-CoV-2 viral load and low CCL5 expression levels in the upper respiratory tract are associated with COVID-19 severity
| Autor: | Felipe Pérez-García, María Martin-Vicente, Rosa Lía Rojas-García, Lucía Castilla-García, María José Muñoz-Gomez, Irene Hervás Fernández, Victoria González Ventosa, Erick Joan Vidal-Alcántara, Juan Cuadros-González, Jesús F Bermejo-Martin, Salvador Resino, Isidoro Martínez |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
CCL5
SARS-CoV-2 viruses Brief Report fungi virus diseases COVID-19 biochemical phenomena metabolism and nutrition Severity of Illness Index nasopharynx viral load Intensive Care Units Infectious Diseases AcademicSubjects/MED00290 death ICU gene expression Humans RNA Viral Immunology and Allergy skin and connective tissue diseases Chemokine CCL5 innate immunity |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2–infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity. |
| Databáze: | OpenAIRE |
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