Brain Perfusion Correlates of Apathy in Alzheimer's Disease
| Autor: | Yong-An Chung, YoungSoon Yang, In-Uk Song, Seunghee Na, Hyeonseok S. Jeong, Jooyeon Jamie Im, Jong-Sik Park, Ilhyang Kang, Youngje Heo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Neurology Apathy Perfusion scanning Alzheimer's Disease 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Tomography Emission-Computed Single-Photon Neural correlates of consciousness 030214 geriatrics business.industry Cerebral blood flow nervous system Regional Blood Flow Cardiology Orbitofrontal cortex Original Article medicine.symptom business Insula Perfusion 030217 neurology & neurosurgery |
| Zdroj: | Dementia and Neurocognitive Disorders |
| ISSN: | 2384-0757 |
| Popis: | Background and Purpose Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer's disease (AD). It may have adverse impacts on the progression of AD. However, its neurobiological underpinnings remain unclear. The objective of this study was to investigate differences in regional cerebral blood flow (rCBF) between AD patients with apathy and those without apathy. Methods Sixty-six apathetic AD patients and 66 AD patients without apathy completed Neuropsychiatric Inventory (NPI) and underwent technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) scans. Voxel-wise differences in rCBF between the 2 groups were examined. Association between rCBF and levels of apathy in the apathetic group was also assessed. Results AD patients with apathy showed lower rCBF in the bilateral orbitofrontal cortex, left putamen, left nucleus accumbens, left thalamus, and bilateral insula than those without (all p |
| Databáze: | OpenAIRE |
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