Aptamers in Targeted Nanotherapy
| Autor: | D. Sakthikumar, Anila Mathew, Toru Maekawa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Antibiotics Antineoplastic Oligonucleotide Aptamer SELEX Aptamer Technique Prostatic Neoplasms Nanotechnology General Medicine Aptamers Nucleotide Biology Theranostic Nanomedicine Molecular Imaging Small Molecule Libraries Mice Drug Delivery Systems Doxorubicin Drug Discovery Drug delivery Animals Humans Nanoparticles Nanomedicine Molecular Targeted Therapy Aptamers Peptide Targeting ligands |
| Zdroj: | Current Topics in Medicinal Chemistry. 15:1102-1114 |
| ISSN: | 1568-0266 |
| Popis: | The use of aptamers as targeting molecules has revolutionized nanomedicine. Aptamers are short oligonucleotides or peptides that can be used as targeting ligands against numerous targets. Aptamers are versatile moieties that can be used both in therapeutic and targeting applications. Aptamers bind to the target in a process that is similar to the lock and key mechanism. There are numerous reports on the use of aptamers as targeting moieties for imaging and drug delivery applications. In this review, we would like to give a comprehensive report on aptamers, its properties and the developments in aptamer mediated drug delivery in the recent years. |
| Databáze: | OpenAIRE |
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