The Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia–Reperfusion Injury
| Autor: | Bülent Akçora, İsmet Melek, Tünay Kontaş, Taskin Duman, Esin Atik, I Fansa, Muhammed Enes Altuğ, E. Ucar |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.drug_class Anti-Inflammatory Agents Nitric Oxide Biochemistry Neuroprotection Anti-inflammatory Proinflammatory cytokine Diltiazem Malondialdehyde Animals Medicine Interleukin-6 Spinal Cord Ischemia business.industry Biochemistry (medical) Aortic occlusion Cell Biology General Medicine Spinal cord medicine.disease Glutathione Interleukin-10 Neuroprotective Agents medicine.anatomical_structure Reperfusion Injury Spinal cord ischaemia Anesthesia cardiovascular system Rabbits business Reperfusion injury medicine.drug |
| Zdroj: | Journal of International Medical Research. 37:520-533 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000903700228 |
| Popis: | The protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia–reperfusion induced by infrarenal aortic occlusion for 30 min. In the diltiazem group ( n = 6), an intravenous infusion (2 μg/kg per min) was started 10 min before ischaemia induction; normal saline solution was infused in the control group ( n = 6). Neurological function was assessed using modified Tarlov criteria 24 h after surgery. Plasma samples were analysed for interleukin (IL)-6 and IL-10. Spinal tissue was analysed for malondialdehyde, nitric oxide and reduced glutathione activities. Tarlov scores of the diltiazem-treated rabbits indicated significantly improved hind-limb motor function compared with the control group. The diltiazem group also had better quantitative and qualitative histopathological findings. Diltiazem infusion significantly reduced IL-6 levels 3 and 24 h after reperfusion compared with the control group. The mean IL-10 level in the diltiazem group was significantly higher than in the control group 24 h after reperfusion. It is concluded that diltiazem has cytoprotective and anti-inflammatory properties, leading to reduced spinal cord injury. |
| Databáze: | OpenAIRE |
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