AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression

Autor: He‐Hsiung Cheng, Lin Hung‐Ke, Meei‐Ling Sheu, Chun‐Yi Lee, Yi‐Ching Tsai, De‐Wei Lai
Rok vydání: 2022
Předmět:
Zdroj: ImmunologyREFERENCES.
ISSN: 1365-2567
Popis: The prognosis of systemic lupus erythematosus (SLE) is unpredictable. This study aimed to examine the regulatory mechanism of the AHR/TET2/NT5E pathway during SLE progression. The AHR, TET2 and NT5E expression levels were examined in T regulatory cells (Tregs) of patients with SLE. The correlation of AHR, TET2 or NT5E expression levels with the immunosuppressive functions of Tregs was analysed. In patients with SLE, the number of CD4
Databáze: OpenAIRE