Prevention of traveler's diarrhea by the tablet form of bismuth subsalicylate
| Autor: | Robert Steffen, F Witassek, M Schär, M D Manhart, A Helminger, R. Heusser, H. L. DuPont |
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| Rok vydání: | 1986 |
| Předmět: |
Diarrhea
medicine.medical_specialty Shigella dysenteriae Traveler's diarrhea Nausea Placebo Bismuth subsalicylate Oral administration Internal medicine Organometallic Compounds Humans Medicine Pharmacology (medical) Volunteer Pharmacology Travel business.industry medicine.disease Salicylates Surgery Regimen Infectious Diseases Salmonella enteritidis Patient Compliance medicine.symptom business Bismuth Research Article Tablets medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 29:625-627 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.29.4.625 |
| Popis: | In a randomized double-blind study, Swiss adults traveling to tropical countries for 12 to 28 days took a solid formulation of bismuth subsalicylate (1.05 or 2.1 g/day on a twice-daily regimen) or placebo. Efficacy was evaluated in 231 volunteers. Diarrheal incidence was reduced by 41% in persons taking the high dose (P = 0.007) and by 35% in those taking the low dose (P = 0.03) with excellent compliance. No serious adverse reactions occurred, but objectionable taste, constipation, and nausea were seen more frequently with active medication (P = 0.04). Twenty patients provided stool samples: no bacteria were detected in the 8 volunteers who were on active medication, but various bacteria were found in 5 of the 12 patients who had taken placebo (P = 0.04). |
| Databáze: | OpenAIRE |
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