Osteoprotegerin and B-type natriuretic peptide in non-ST elevation acute coronary syndromes: Relation to coronary artery narrowing and plaques number
| Autor: | Ranuccio Nuti, Maria Stella Campagna, Beatrice Franci, Alberto Palazzuoli, Anna Calabrò, Vittoria Rizzello, Giuseppe Martini, Maddalena Gallotta, Ilaria Quatrini |
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| Rok vydání: | 2008 |
| Předmět: |
Male
musculoskeletal diseases Acute coronary syndrome medicine.medical_specialty medicine.drug_class Clinical Biochemistry Coronary Angiography Biochemistry Angina Pectoris Coronary artery disease Osteoprotegerin Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans cardiovascular diseases Myocardial infarction Acute Coronary Syndrome Coronary atherosclerosis Aged Unstable angina business.industry ST elevation Biochemistry (medical) General Medicine Middle Aged medicine.disease Cardiology Female business |
| Zdroj: | Clinica Chimica Acta. 391:74-79 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2008.02.008 |
| Popis: | To analyse osteoprotegerin (OPG), and B-type natriuretic peptide (BNP) levels in patients with non-ST elevation acute coronary syndrome (NSTE-ACS), in relation to clinical presentation and to coronary atherosclerosis diffusion. OPG has been found in several tissues, including the cardiovascular system, BNP is selectively produced by myocardial cells.178 consecutive patients were classified in three groups: stable angina (SA), unstable angina/non-ST elevation myocardial infarction (NSTE-ACS) and control group, measuring OPG and BNP at hospital admission. We compared both biomarkers in relation to the number of coronary narrowed vessels (1-, 2- , 3- or 4- vessels disease), and to the stenoses degree by Duke Jeopardy score.OPG levels were higher in patients respect to controls (p0.0001). Patients with SA showed more elevated levels than controls (2.6+/-1.2 vs 7.4+/-5.0 pmol/l p0.01). However patients with NSTE-ACS had higher OPG level with respect to SA patients (11.8+/-7.1 pmol/l p0.001). A positive relation was found between OPG levels and number of coronary plaques by Duke Jeopardy score (r=0.65). BNP levels were higher in patients with NSTE-ACS respect to controls and SA patients (p0.001). Besides, BNP was significantly higher in multivessels vs 1-vessel disease (p0.001).Patients with NSTE-ACS show high OPG levels. OPG increase seems related to the number of plaques in the coronary vessels, suggesting its involvement in the coronary disease progression. BNP is also increased during NSTE-ACS and more associated to coronary narrowing. |
| Databáze: | OpenAIRE |
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