The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment
| Autor: | Jesper Johannesen, Cilius Esmann Fonvig, Torben Hansen, Oluf Pedersen, Tenna Ruest Haarmark Nielsen, Michael Gamborg, Jens-Christian Holm, Julie T. Kloppenborg |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Pediatric Obesity Prediabetic State/blood Adolescent Glycated Hemoglobin A/metabolism Endocrinology Diabetes and Metabolism medicine.medical_treatment Physiology 030209 endocrinology & metabolism Overweight Childhood obesity Body Mass Index Prediabetic State 03 medical and health sciences Young Adult 0302 clinical medicine Weight loss Internal medicine Glucose Intolerance Weight Loss Internal Medicine medicine Humans Insulin 030212 general & internal medicine Prediabetes Longitudinal Studies Child Glucose Intolerance/blood Weight Reduction Programs/statistics & numerical data Glycated Hemoglobin C-Peptide business.industry medicine.disease Obesity Pediatric Obesity/blood Weight Reduction Programs Endocrinology Pediatrics Perinatology and Child Health C-Peptide/blood Median body Female medicine.symptom business Insulin/blood Body mass index |
| Zdroj: | Kloppenborg, J T, Gamborg, M, Fonvig, C E, Nielsen, T R H, Pedersen, O, Johannesen, J, Hansen, T & Holm, J-C 2018, ' The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment ', Pediatric Diabetes, vol. 19, no. 3, pp. 366-374 . https://doi.org/10.1111/pedi.12605 |
| ISSN: | 1399-5448 |
| DOI: | 10.1111/pedi.12605 |
| Popis: | OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment.METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up. Proxies of Homeostasis Model Assessment 2-insulin sensitivity (HOMA2-IS) and Homeostasis Model Assessment 2-β-cell function (HOMA2-B) were calculated with the Homeostasis Model Assessment 2 program.RESULTS: In total, 569 (333 boys) patients, median 11.5 years of age (range 6-22 years), and median body mass index (BMI) z-score 2.94 (range 1.34-5.54) were included. The mean BMI z-score reduction was 0.31 (±0.46) after 13 months (range 6-18) of treatment. At treatment entry, patients with impaired estimates of glucose metabolism were more obese than normoglycemic patients. Baseline concentration of C-peptide was associated with a lower weight loss during treatment in girls (P = .02). Reduction in the insulin concentrations was associated with reduction in BMI z-score in both sexes (P CONCLUSION: The capability to reduce weight during multidisciplinary treatment in children and adolescents with overweight/obesity is not influenced by an impaired glucose metabolism at study entry or during the course of treatment. |
| Databáze: | OpenAIRE |
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